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PLXNA4 Antibody, Biotin conjugated

Datasheet
Code CSB-PA862071LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLXNA4 Polyclonal antibody
Uniprot No.
Q9HCM2
Target Names
PLXNA4
Alternative Names
FAYV2820 antibody; KIAA1550 antibody; PLEXA4 antibody; Plexin-A4 antibody; PlexinA4 antibody; PLXA4_HUMAN antibody; plxna4 antibody; PLXNA4A antibody; PLXNA4B antibody; PRO34003 antibody; UNQ2820/PRO34003 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Plexin-A4 protein (24-522AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Gene References into Functions
  1. Both CLU and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU-PLXNA4 interactions may have therapeutic value in AD. PMID: 27378688
  2. There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4. PMID: 25043464
  3. Rare variants in PLXNA4 and Parkinson's disease. PMID: 24244438
  4. Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. PMID: 21832283
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Families
Plexin family
Database Links

HGNC: 9102

OMIM: 604280

KEGG: hsa:91584

STRING: 9606.ENSP00000323194

UniGene: Hs.511454

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